Angela M. DeMichele, MD, MSCE, FASCO

Angela M. DeMichele, MD, MSCE, FASCO, is a professor of medicine at the Perelman School of Medicine at the University of Pennsylvania, where she holds the Mariann T. and Robert J. MacDonald Chair in Breast Cancer Research. She also serves as co-leader of the Breast Cancer Research Program in the Abramson Cancer Center (a program rated as “exceptional” by the National Cancer Institute), director of clinical/translational research in solid oncology in the Division of Hematology/Oncology, and a senior scholar in the Center for Clinical Epidemiology and Biostatistics, all at the Perelman School of Medicine at the University of Pennsylvania.

Dr DeMichele received her undergradate degree in biochemistry from Brown University and her medical degree from Washington University School of Medicine in St. Louis. She subsequently completed her residency in internal medicine and a fellowship in medical oncology at the University of Pennsylvania, where she also received her master of science in clinical epidemiology degree before joining the faculty.

Internationally recognized for her research in breast cancer drug development, translational epidemiology, and biomarker-driven clinical trials, Dr DeMichele’s work focuses on the detection and treatment of minimal residual disease and the prevention of breast cancer recurrence. She is co-director of the University of Pennsylvania’s 2-PREVENT Breast Cancer Translational Center of Excellence, where she leads a multidisciplinary team dedicated to preventing breast cancer recurrence through studies on the detection and eradication of dormant and reactivating molecular residual disease following primary treatment. Dr DeMichele has also played a pivotal role in the development of the first CDK4/6 inhibitor, palbociclib, and led the I-SPY2 trial in graduating several new agents in the neoadjuvant setting that increase pathologic complete response.

Nationally, Dr DeMichele serves as chair of the ECOG-ACRIN Cancer Research Group Breast Cancer Committee, co–principal investigator for the I-SPY trial, and a member of the St. Gallen Early Breast Cancer Consensus Panel. She has also served on numerous committees for the American Society of Clinical Oncology, including as scientific program chair in 2024. She has received funding from the National Institutes of Health, the US Department of Defense, the Breast Cancer Research Foundation, Susan G. Komen, and other foundations. Dr DeMichele has authored more than 150 peer-reviewed publications in high-impact journals, including The New England Journal of Medicine, Nature Medicine, the Journal of Clinical Oncology, and JAMA. Her work has been recognized with the Pennsylvania Breast Cancer Coalition Potamkin Prize for Breast Cancer Research and the 2023 American Society of Clinical Oncology Gianni Bonadonna Breast Cancer Award.