Neurology

Alzheimer's Disease

Expert Roundtables Podcast: The Importance of Amyloid-β From the Diagnosis of Alzheimer’s Disease to Its Treatment

expert roundtables by Marc E. Agronin, MD; Anton P. Porsteinsson, MD; Vijay K. Ramanan, MD, PhD

Overview

<p>Advances in biomarker technology now allow for the earlier and more accurate detection of amyloid pathology. With the recent US Food and Drug Administration (FDA) approvals of amyloid-β (Aβ)–targeting therapies, clinicians are entering a new era of disease-modifying treatment that raises important questions about patient selection, timing, and long-term outcomes. Listen to today’s podcast to learn more.</p>

References

Parent C, Rousseau LS, Predovan D, Duchesne S, Hudon C. Longitudinal association between ß-amyloid accumulation and cognitive decline in cognitively healthy older adults: a systematic review. Aging Brain. 2023;3:100074. doi:10.1016/j.nbas.2023.100074

Pokrzyk J, Kulczyńska-Przybik A, Guzik-Makaruk E, Winkel I, Mroczko B. Clinical importance of amyloid beta implication in the detection and treatment of Alzheimer’s disease. Int J Mol Sci. 2025;26(5):1935. doi:10.3390/ijms26051935

Sims JR, Zimmer JA, Evans CD, et al; TRAILBLAZER-ALZ 2 Investigators. Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial. JAMA. 2023;330(6):512-527. doi:10.1001/jama.2023.13239

Thakor VS, Tyagi A, Lee JM Jr, Coffman F, Mittal R. Alois Alzheimer (1864-1915): the father of modern dementia research and the discovery of Alzheimer’s disease. Cureus. 2024;16(10):e71731. doi:10.7759/cureus.71731

van Dyck CH, Swanson CJ, Aisen P, et al. Lecanemab in early Alzheimer’s disease. N Engl J Med. 2023;388(1):9-21. doi:10.1056/NEJMoa2212948

Profile

Marc E. Agronin, MD

Chief Medical Officer
Frank C. and Lynn Scaduto MIND Institute and Behavioral Health
Miami Jewish Health
Affiliate Associate Professor of Psychiatry and Neurology
University of Miami Miller School of Medicine
Miami, FL

Profile

Anton P. Porsteinsson, MD

William B. and Sheila Konar Professor of Psychiatry
Professor of Neurology, Neuroscience, and Medicine
Director, Alzheimer’s Disease Care, Research and Education (AD-CARE) Program
University of Rochester School of Medicine and Dentistry
Rochester, NY